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How can the latent cytomegalovirus cause an increase in all-cause mortality? An answer based on the microcompetition model

Hanan Polansky

Corresponding author name: Hanan Polansky
Corresponding author e-mail: hpolansky@cbcd.net

Citation: Antiviral Therapy 2020; 25:349-351
doi: 10.3851/IMP3384

Date accepted: 09 February 2021
Date published online: 22 February 2021

Abstract

Many studies showed the existence of a positive association between cytomegalovirus (CMV) seropositivity and all-cause mortality. In this paper, we use the microcompetition model to explain how the latent CMV sequesters the limiting GABP∙p300/CBP transcription complex, which causes abnormal cellular gene expression, a chronic disease and mortality. Since most people harbour the latent CMV, we urge further research on this topic.

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