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Original article

Antiviral activity of different extracts of standardized propolis preparations against HSV

Sevda Demir, Ali Timucin Atayoglu, Fabio Galeotti, Emanuele U Garzarella, Vincenzo Zaccaria, Nicola Volpi, Ali Karagoz, Fikrettin Sahin

Corresponding author name: Ali Timucin Atayoglu
Corresponding author e-mail: atatayoglu@medipol.edu.tr

Citation: Antiviral Therapy 2020; 25:353-363
doi: 10.3851/IMP3383

Date accepted: 04 February 2021
Date published online: 23 February 2021


Background: Viral infections are among the most common problems in health-care practice. Natural products offer great promise as potentially effective antiviral drugs. Propolis is a honeybee product with biological properties and therapeutic applications. We aimed to investigate the antiviral activity of different extracts of Standardized Propolis Preparations (M.E.D.®) with glycol, ethanol, glycerol and soya oil, against herpes simplex type-1 (HSV-1) and type 2 (HSV-2) viruses.

Methods: Chemical composition and antiviral activity of each extract were determined. The selective index (SI=CC50/EC50) was determined as a parameter to indicate the in vitro antiviral activity of the extracts compared with acyclovir as the control.

Results: SI values of glycol, ethanol, glycerol, soya oil extracts and acyclovir were determined as 6.8, 4.1, 2.2, 3.3 and 6.3 against HSV-1, and as 6.4, 7.7, 1.9, 4.2 and 2.9 against HSV-2, respectively. Glycolic propolis extract was found to possess a greater antiviral activity than acyclovir for both HSV-1 and 2, while glycolic, ethanolic and soya oil preparations were found to have more significant activity than acyclovir for HSV-2.

Conclusions: It was determined that standardized propolis preparations have antiviral bioactivity against HSV.


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