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Case report

Combination antiviral therapy with lopinavir/ritonavir, arbidol and interferon-α1b for COVID-19

Xiangyang Xie, Yuanliang Jiang, Yuan Zeng, Hui Liu

Corresponding author name: Hui Liu
Corresponding author e-mail: 164554119@qq.com

doi: 10.3851/IMP3362

Abstract

Since the outbreak of coronavirus disease (COVID-19) that was discovered in 2019 in Wuhan, China, no standard therapy guideline has been set despite the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its high infectivity. The globally pandemic outbreak suggests that COVID-19 was highly infectious and difficult to control. A dual-combination of ribavirin and interferon-α has been the widely used regimen for the treatment of this disease in China. However, due to the varying results of treatment with these drugs, a novel antiviral combination therapy is urgently needed. This case reports the usage of lopinavir/ritonavir-based combination antiviral regimen for a patient with SARS-CoV-2 infection.

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