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Case report

Multidrug-resistant cytomegalovirus infection in a patient with granulomatosis with polyangiitis during immunosuppressive treatment

Giulia Piccirilli, Angela Chiereghin, Martina Maritati, Gabriele Turello, Silvia Felici, Renato La Corte, Liliana Gabrielli, Carlo Contini, Tiziana Lazzarotto

Corresponding author name: Carlo Contini
Corresponding author e-mail: cnc@unife.it

Citation: Antiviral Therapy 2020; 25:111-114
doi: 10.3851/IMP3352

Date accepted: 27 February 2020
Date published online: 16 April 2020

Abstract

Cytomegalovirus (CMV) infection is a major complication in immunocompromised patients, including those with autoimmune diseases. Here, we describe the first case of granulomatosis with polyangiitis treated with steroids and cyclophosphamide, complicated by a multidrug-resistant (MDR) CMV infection in presence of weak antiviral cellular immunity. Since reports regarding CMV infection in rheumatological patients are rarely described and no guidelines on its management exist, the described case contributes to identify potential strategies to predict the risk of CMV disease and developing of MDR-CMV in these patients, through virological and immunological surveillance.

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