About AVT
Browse Articles
Authors
Customer Services

Original article

Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-α2a treatment

Ingmar Mederacke, Cihan Yurdaydin, George N Dalekos, Birgit Bremer, Andreas Erhardt, Yilmaz Cakaloglu, Kendal Yalcin, Selim Gurel, Stefan Zeuzem, Kalliopi Zachou, Hakan Bozkaya, Hans Peter Dienes, Michael P Manns, Heiner Wedemeyer, Hep-Net/International Delta Hepatitis Study Group

Corresponding author name: Heiner Wedemeyer
Corresponding author e-mail: wedemeyer.heiner@mh-hannover.de

Citation: Antiviral Therapy 2012; 17:305-312
doi: 10.3851/IMP1926

Date accepted: 25 May 2011
Date published online: 24 October 2011

Abstract

Background: The role of anti-HDV immunoglobulin M (IgM) testing in patients receiving pegylated interferon-α therapy for hepatitis delta is unknown. We performed anti-HDV IgM testing in a well defined cohort of HDV-infected patients who were treated with pegylated interferon-α2a plus adefovir, or either drug alone.

Methods: Sera from 33 HDV-RNA-positive patients from the international HIDIT-1 trial were available for anti-HDV IgM testing (ETI-DELTA-IGMK-2 assay, DiaSorin, Saluggia, Italy) before therapy, at treatment weeks 24 and 48, and at 24 weeks after the end of treatment.

Results: Anti-HDV IgM tested positive in 31 out of the 33 patients (94%) prior to treatment. HDV IgM levels correlated with histological inflammatory activity (r=0.51, P<0.01) and were higher in patients with alanine aminotransferase and γ-glutamyl transpeptidase levels above the median (P<0.05). Quantitative anti-HDV IgM values declined in patients responding to antiviral therapy, however anti-HDV IgM remained positive after treatment in the majority of virological responders.

Conclusions: We suggest that anti-HDV IgM testing might give additional useful information to determine disease activity in hepatitis delta and to predict treatment response to antiviral therapy with type I interferons. However, determination of anti-HDV IgM can not substitute HDV RNA testing, which remains the primary virological marker for response to therapy.

<< BACK

Copyright © Nucleus Global 2017. Part of Nucleus Global.
Design and Technology by Nucleus Global
Company registration No. 321 0712 (England & Wales). Registered Office address: Admiral House 76-78 Old Street, London EC1V 9AZ.