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Case report

Prolonged shedding of amantadine- and oseltamivir-resistant influenza A(H3N2) virus with dual mutations in an immunocompromised infant

Guillermo Ruiz-Carrascoso, Inmaculada Casas, Francisco Pozo, Marta González-Vincent, Pilar Pérez-Breña

Corresponding author name: Guillermo Ruiz-Carrascoso
Corresponding author e-mail: guille2003@hotmail.com

Citation: Antiviral Therapy 2010; 15:1059-1063
doi: 10.3851/IMP1657

Date accepted: 21 April 2010
Date published online: 08 September 2010

Abstract

In this study, we report a case of multidrug-resistant influenza A(H3N2) virus isolated from an immunosuppressed patient with prolonged viral shedding. We also describe the genetic characterization of the haemagglutinin, neuraminidase and M2 influenza genes. The virus contained the substitutions E119V in neuraminidase and V27A in M2, which produce resistance to oseltamivir and adamantanes, respectively. This is the first report of this dual mutation pattern in multidrug-resistant influenza A(H3N2) virus.

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