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Antiretroviral drugs to prevent breastfeeding HIV transmission

Lynne M Mofenson

Corresponding author name: Lynne M Mofenson
Corresponding author e-mail: LM65D@nih.gov

Citation: Antiviral Therapy 2010; 15:537-553
doi: 10.3851/IMP1574

Date accepted: 05 April 2010
Date published online: 25 June 2010

Abstract

Observational studies and randomized clinical trials demonstrating that antiretroviral prophylaxis of the breastfeeding infant or triple-drug antiretroviral prophylaxis of the lactating mother can significantly affect the risk of postnatal transmission of HIV via breast milk have recently become available. In resource-limited countries, breastfeeding is a cornerstone of infant survival. While shortening the duration of breastfeeding by HIV-infected women reduces postnatal HIV transmission, increasing data suggest this may also decrease overall infant survival. Thus, there is a crucial need for interventions to allow safer and more prolonged breastfeeding. This paper will critically review the results of studies of postnatal antiretroviral prophylaxis to prevent breast milk HIV transmission.

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