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Case report

Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Carmela Pinnetti, Enrica Tamburrini, Enzo Ragazzoni, Andrea De Luca, Pierluigi Navarra

Corresponding author name: Carmela Pinnetti
Corresponding author e-mail: carmenpinnetti@yahoo.it

Citation: Antiviral Therapy 2010; 15:127-129
doi: 10.3851/IMP1473

Date accepted: 20 August 2009
Date published online: 06 January 2010

Abstract

We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.

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