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Original article

Oxidant stress in HIV-infected women from the Women’s Interagency HIV Study

Marshall J Glesby, Donald R Hoover, Farbod Raiszadeh, Irene Lee, Qiuhu Shi, Ginger Milne, Stephanie C Sanchez, Wei Gao, Robert C Kaplan, Jason D Morrow, Kathryn Anastos

Corresponding author name: Marshall J Glesby
Corresponding author e-mail: mag2005@med.cornell.edu

Citation: Antiviral Therapy 2009; 14:763-769
doi: 10.3851/IMP1290

Date accepted: 27 January 2009
Date published online: 05 October 2009

Abstract

Background: Oxidant stress contributes to the pathogenesis of multiple conditions and can be assessed by measuring plasma F2-isoprostane concentrations. We hypothesized that oxidant stress is associated with plasma homocysteine concentration and risk factors for atherosclerosis in HIV-infected women.

Methods: We measured plasma F2-isoprostane concentrations in a cross-sectional study of 249 HIV-infected women attending the Bronx (NY, USA) site of the Women’s Interagency HIV Study and assessed associations with plasma homocysteine concentration and other metabolic parameters by linear regression.

Results: In multivariate analysis, hepatitis C virus (HCV) viraemia, waist circumference, homocysteine concentration and serum aspartate aminotransferase level were positively associated with log F2-isoprostane concentration (all P<0.005). There was a trend for an inverse association between log F2-isoprostane and CD4+ T-cell percentage (P=0.06). Among women with HCV infection, the FIB-4 index, an indirect marker of liver fibrosis derived from routine laboratory tests, was positively associated with log F2-isoprostane concentration.

Conclusions: In this cross-sectional study of HIV-infected women, plasma F2-isoprostane concentration was positively associated with homocysteine concentration, as well as HCV infection, abdominal obesity and aspartate aminotransferase level.

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