Host genetics influences on HIV type-1 diseaseJacques Fellay
Corresponding author name: Jacques Fellay
Corresponding author e-mail: email@example.com
Citation: Antiviral Therapy 2009; 14:731-738
Date published online: 04 September 2009
HIV host genetic studies seek to describe as comprehensively as possible the effect of human genetic variation on the individual response to HIV type-1 (HIV-1) infection. Many associations between specific gene variants and HIV-1 disease outcomes have been reported over the past 15 years. Although most of them have yet to be confirmed or have been proven false-positives, the identification of several definitive genotype–phenotype associations has shed new light on HIV-1 pathogenesis. This review discusses these results in the context of the new genome-wide approaches that now make it possible to globally assess the influence of the host genome on HIV-1-related outcomes.